Parkinson's treatment
Because Parkinson's disease occurs due to an increase in dopamine deficiency in the areas of nerve synapses and muscles for multiple reasons, we want to supply dopamine in any of these ways:
Dopamine in medicinal form is called: Levodopa, Carbidopa.
Mechanism of action:
Oral is taken and absorbed through the digestive system.
Before absorption, metabolism occurs in the stomach, leading to problems in the digestive system and sometimes problems in the central system of the heart, causing irregular heartbeats and may lead to low blood pressure.
Tyrosine turns dopa into dopamine, which is the form the body can process.
To reduce digestive system problems when taking Levodopa alone, it is given in combination with Carbidopa, which reduces metabolism in the stomach, so problems decrease.
The process of dopamine decarboxylase is inhibited, and levodopa is converted due to the presence of carbidopa into dopa, which is converted directly into dopamine.
Uses:
Levodopa is used to treat Parkinson's disease, stiffness, and tremors in combination with Carbidopa to reduce the side effects of Levodopa.
Side Effects:
It causes side effects on the main and peripheral parts, for example, it causes the accumulation of dopamine in the synaptic areas, which may lead to fluctuations:
depression, mood disturbance, tension, hallucinations, anxiety...
Heart problems, acceleration, and differences in blood pressure and blood pumping.
Stomach disorders cause nausea and vomiting.
Therefore, the drug will be withheld from people who suffer from any heart muscle disease, erythremia, or medications that increase the secretion of dopamine and catecholamine in the blood. You should be careful with medications that raise blood pressure.
---- You must be careful of withdrawal effects, so take the medication gradually.