Wet granulation
Wet granulation is a mixture of dry primary powder particles with granulating fluid followed by drying so that these liquids used contain a solvent which must be volatile and non-toxic.
In particular, the liquid must contain a volatile solvent in order to remove the liquid during the drying process, because the process of making granules must include several steps, as follows: wet granulation and then dry granulation. Therefore, the liquid must contain a volatile solvent to remove it during the drying process.
What fluids are used in wet granulation?
Water and ethanol are added either alone or combined, meaning that either water is added alone, or ethanol is added alone, or water and ethanol are added together, and so on.
Can liquids be added to granulation?
Yes, liquids such as water and ethanol are added to granulation, but these drugs must be stable with heat and humidity, so that drugs that are not stable with heat or humidity or both cannot add liquids to granulation, although adding liquid to granulation is very important in the wet granulation process, but Such unstable medicines with heat and humidity, so we do not add any liquid