This is a medical health-concerned blog, we will be explaining different types of illnesses and diseases and how we can treat them by taking medical drugs.
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Not all medicines must be coated, and they do not dissolve except in the intestines, and they will not disintegrate or dissolve except in the intestines. It is true that there is a wider area and more capillaries, but the stomach also needs medicines, for example, hyperacidity.
Tablet disintegration test:
There are medicines that are taken for the purpose of being absorbed locally in the stomach for the indication of the environment and stomach problems such as acidity and diarrhea caused by the environment of the stomach, so it disintegrates in the stomach with its enzymes and acids.
The tablet prepares itself for absorption when it disintegrates, and displays the largest amount of the tablet for interactions with the environment and mixes with stomach and body fluids to give its effect.
If the coated tablet was disintegrating in the stomach, it would take a lot of time, such as an hour and three hours, for it to disintegrate! In addition to medications given through the buccal cavity.
Disintegration test mechanism
This is done in the laboratory through a special device to disassemble the uncoated tablet and capsule and put the pills in the tubes of each pill separately and put them in distilled water liquid similar to the surroundings of the human stomach. The tubes begin to move up and down at a rate of approximately 30 revolutions per minute, up to a certain period, according to the pills that were placed, for example, a quarter of an hour. Note the time with the occurrence of the first disintegration. If disintegration occurs for a number of pills whose percentage is more than two out of 18 (16/18), the sample is rejected and returned to manufacturing.
Attention must be paid to the temperature, of course, of 37 degrees, with the natural human body temperature, so that disintegration is not affected by environmental factors.
