Tablets Formulation ( Excipients)
In general, the formulation of the tablets contains the active ingredient, which is the drug, and the inactive ingredient, which is the excipients or adjuncts. For example, there are tablets that give a local effect, such as antacid, that treat some diseases of the digestive system without absorption from the digestive system to the systemic system. There are also tablets that have a systemic effect so that they dissolve In the digestive system and it is absorbed into the systemic system to be distributed throughout the body, and all this can be controlled through the justifications and the main goal of the drug.
Why are excipients used during the manufacture of tablets?
1- Sometimes the use of excipients in the manufacture of tablets is useful in facilitating the manufacture of tablets.
2- The use of excipients in tablets enhances the bioavailability of the drug.
3- The use of excipients in the manufacture of pharmaceutical tablets benefits the mechanical and physical acceptance of tablets.
The ideal properties that must be available in the excipients to be used in the manufacture of pharmaceutical tablets:
1- The excipients should have inert elements and not cause poisoning to the patient when used.
2- The excipients must be pure and free from any contamination.
3- It must be compatible with the excipients, so that the excipients do not interact with each other, interact with the drug itself, or affect the absorption of the drug or the properties of the drug.
4- That the excipients do not affect the physiochemical stability of the drug.
5- That the headphones do not affect the absorption of the drug or the efficacy of the drug.
6- From an economic point of view, the excipients must be inexpensive and cheap.
When tablets contain a high percentage of excipients and when it is low?
1- In small doses (less than 25 mg): Most tablets contain excipients.
2- In high doses (more than 250 mg): most of the tablet will be drugs or what is called the active ingredient.