Multi components of tablets ( Glidants And Binder )
1- Glidants
Definition:
They are substances added to the components of the tablet to enhance and improve the flow of powder and granules from the hopper and into direct die cavity (1%). This may help regulate the weight of the tablet.
What happens when the powder and granules have a poor flow?
When the flow is weak for padour and granules, this leads to irregular tablets weight, so we notice that there are tablets that contain less drug weight than other tablets in the same package.
The main goal of adding glidants to the tablet components?
Adding glidants to tablet components helps to enhance the flowability of direct compression mixtures, this occurs by reducing interparticulate friction.
Relationship between angle of repose and flow:
When adding glidants to powder or granules, this addition leads to a decrease in the angle of repose, and thus the flow becomes better. When the flow becomes good, this leads to a uniform weight of the tablet.
2- Binder
Definition:
It is also called glues, which is added to the components of the tablets to hold the overall tablet together, which leads to an improvement in the compactness of the tablets , this is useful in the mechanical strength and integrity of the tablets.
Substances that are considered binder and that are added to the components of tablets with concentration (w/w):
1- hydroxypropylmethylcellulose (2-5%)
2- polyvinylpyrrollidone (0.5-5%)
3- hydroxymethylcellulose (2-6%)
4- acacia (1-5%)
5- microcrystalline cellulose (20-90%)
6- sucrose (50-65%)