Granules despite the presence of powders !!!
Powders are made instead of powders for several reasons, the most important of which is storage. Why? The two types consist of the same active ingredients!
when preparing to mix materials with some active materials and excipients, often these materials will not be the same size, and sedimentation will occur under any circumstances, whether manually and errors during pregnancy and manufacture, or automatically from a grinding machine, for example, to make the particle the same size.
Sedimentation and separation will occur according to the particle density, shape and other factors.
The granules are excellent in flow compared to powders, as the granules are equal in characteristics called spherical ball, and there will be no pins or very smooth or square-shaped objects, sedimentation and overlapping of components.
Cake occurs in powders when it is left for some periods or exposed to moisture or heat, so it needs a certain temperature to prevent cake and adhesion of granules between each other and on the adjacent surface compared to spherical-shaped glomeruli that stick to each other and the surrounding wall with one point between its surface and the surrounding surface, whether granular or a wall .
The outer space of the powder that is subject to interaction is more because the more the surface areas of the particle increase, the less the size of this particle, so the percentage of interactions with any air or mechanical factor or what is more related to its pressure inside the tablet.