Adrenergic agonist to treat asthma
Classified as :
Short acting :
Albuterol, Salbutamol , Levalbuterol
long acting:
Arformoterol , Formoterol , indacaterol , salmeterol , vilanterol
Mechanism of action:
- This class of drugs inhibits adenylyl cyclase to prevent the release of large amounts of adenosine and acetylcholine that lead to bronchospasm in the bronchi.
- This class of drugs acts on the beta 2 receptors found in the lungs, so they are Adrenergic B2 agonist ( specific ) .
Uses:
- Do not use this type of medicine on crisis patients alone, it should be used in combination with cortisone, especially in long term B2 agonist.
- It works as an anti-inflammatory.
- In primitive cases, crisis situations must be treated quickly through the short term B2 agonist.
- It is used when exercising to prevent bronchospasm .
Side effects:
- Because of the systemic nature of the drug, it will work to reduce the level of magnesium and potassium in the body and increase the levels of sugar.
- It acts on skeletal muscle swelling due to the drug's specificity on beta-2 receptors .
Drug-Drug interactions:
- In cases of chronic crisis patients, this drug will not work on its own as a treatment for the crisis, and it will worsen with the passage of time, so a drug must be taken in combination with it, for example, corticosteroids.
Precautions:
- There are drugs such as epinephrine and norepinephrine that work on beta 2 in the lung, but they are not specialized only in beta 2, but they will work on beta 1 that is on the heart muscle and increase the rate and force of contraction .
- Caution should be taken with patients with heart diseases, as it may cause tachycardia .
- Of course, it works to make dilation on the lung and reduce secretion of mucus .