platelets inhibitor GPIb /GpII-IIIa + precautions about aspirin
Mechanism of action :
It is a process of closing the receptor located on the surface of the blood cell in the artery or vein, where the role of this receptor was to link the platelet chain to the wall, which leads to the accumulation and gradual coagulation of the platelets.
Uses :
This class of drugs is used as an adjunct to other anticoagulants such as aspirin or stents to prevent ischemic heart disease, as it is given in the form of IV injections.
Abciximab: It is very effective if other medications have not responded to the treatment of unstable angina .
Side effects:
First, because we prevent blood clotting, the first side effect will be: bleeding, a decrease in the number of platelets (thrombocytopenia), after that, this deficiency leads to a decrease in blood viscosity, which leads to hypotension, because increased viscosity leads to hypertension .
Precautions of aspirin (NSAIDS)
Pregnant women should be careful not to use aspirin in high doses, because this leads to a hole in the heart muscle of the fetus, so it is not recommended after the first three months of pregnancy.
In the case of anyone who wanted to have an operation and was committed to taking aspirin and wanted to have an operation, he must stop aspirin for at least a week so that bleeding does not occur after the operation.
Caution must be taken with III patients, because aspirin works to increase the inflammatory mediator, which leads to an increase in the crisis.
Aspirin raises both preload and afterload in cases of heart and kidney failure .