Phosphodiesterase III inhibitor (cilostazol , Dipyridamole). treatment of Atherosclerosis
Mechanism of action:
When PDE is inhibited, cAMP increases, leading to a decrease in the synthesis of Thromboxane A2, which is responsible for increasing platelet aggregation and causing the construction of blood vessels. When cilostazol, Dipyridamole, and phosphodiesterase are given, cAMP increases, leading to vasodilation.
Pharmacological action and uses:
Cilostazol :
- works to increase the beneficial fats, and their height reduces the risk of heart disease and strokes, and a decrease in triglycerides.
- This medication is used to reduce the symptoms of muscle cramps due to a lack of blood supply . (intermittent claudication) .
Dipyridamole:
- It has a role in affecting the prostacyclin that was increasing the rate of adhesion between the platelets, thus preventing the drug from the rate of aggregation.
- It is in the same combination pill with aspirin to prevent clots .
.side effects:
- severe drop in blood pressure when given IV.
- Heavy bleeding.
- It is the most important side effect.
- headache .
- stomach trouble .
- The cilostazol is characterized by the fact that it works on swelling in the body and separating the derm from the epidermis (Steven's Johnson syndrome)
Precautions:
- It is recommended to take cilostazol on an empty stomach half an hour before eating in the morning.
- Care should be taken not to administer salicylates thrombolytic agent with a PDE inhibitor because it will increase the side effects, especially bleeding.
- It is forbidden to give the drug to heart patients due to the side effect of the drug, which is orthostatic hypotension.