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arrhythmia Class 1C [ flecainide , propafenone ]Pharmacological action, Uses , side effects, contraindication
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arrhythmia Class 1C [ flecainide , propafenone ]Pharmacological action, Uses , side effects, contraindication
Pharmacological action:
Generally they act as sodium channel blockers and will not affect the length or shortness of the stroke .
flecainide: works by blocking both sodium and potassium channels and does not affect beta receptors .
Propafenone: works only to close sodium and does not close potassium channels and affects beta receptors and is classified as non-selective, therefore this drug is not given to patients with pulmonary crisis because the lung contains beta 2 receptors .
The pharmacological action is different, but the mechanism of action is almost the same .
Uses :
It treats the atrial fibrillation, which is the state of the absence of a pulse indicated by the p symbol, and treats the atrial flutter, which is the state of the presence of a double p and not one as normal (T, P, P are not true // T, P normal).
Propafenone: has the advantage of treating myocardial infarcts and tachycardia .
Side effects :
Blurred vision
flushing
dizziness
nausea
pulmonary embolism due to blocking of beta-2 receptors (propafenone) .
Contraindication:
Flecainide should not be used in patients with heart failure because it has negative inotropic effects .
asthma patients propafenone should not be given to this category of patients because it has an effect on beta receptors leading to bronchospasm.
Renal failure: Both drugs are excreted through the kidneys, resulting in accumulation of the drug inside the body, which leads to toxicity. Therefore, caution must be taken and doses should be adjusted according to the patient's condition.
