selective Beta1 blockers (Acebutolol , Atenolol , Betaxolol , Bisoprolol , Esmolol , Metoorolol , Nebivolol )
Pharmacological action:
- Of course, it has no effect on the lung and its diseases, because the lung is specialized in beta 2 receptors, as well as muscles will not be affected in addition to carbohydrate metabolites, unlike fat metabolites, which contain beta 1 receptors...
- It will not cause bronchospasm and will not affect asthma patients .
- There is a special feature only for Nebivolol, as it releases from the cells lining the walls of blood vessels what is called nitric oxide, and it causes a vasodilation effect to reduce blood pressure and the number of heartbeats, so it may cause a feeling of shortness of breath .
Uses :
- Esmolol is used during surgeries often only because it is lower half life and is given intravenously to control irregular heartbeat and blood pressure during the operation.
- This family is used as a first line treatment in cases of chronic high blood pressure and its long-term control, especially with patients with pulmonary crisis.
- Heart failure and other chronic heart diseases .
side effects:
- its only bad thing is that when it specializes in beta-1 receptors, it leads to the release of harmful fats into the blood in large quantities, increasing them and causing hyperlipidemia.
- however, its specialization on beta-1 has reduced other side effects on muscles and blood vessels .
Recommendations:
Care must be taken when determining doses, because the selectivety in this family comes with low doses. In the event that the dose became larger, the specificity on the receptor became less, and the lack of specialization began between beta 1 and beta 2, so the side effects increased in higher doses.