Drugs affecting the autonomic nervous system( Succinylcholine)

 

Drugs affecting the autonomic nervous system( Succinylcholine) 

Structure: 

It is a dicholine ester, and it is a quick response in the body, but it is short duration of action.

Pharmacological action: 

Succinylcholine binds to nicotinic receptors, which leads to depolarization of the joints ( It causes sodium channels to open, which leads to muscle twitching) meaning that it acts like acetylcholine, but it is not broken down as quickly as acetylcholine.

Uses: 

1. Endotracheal intubation 

2. During electroconvulsive shock treatment.

Side effect: 

1- Apnea: due to paralysis of the diaphragm.

2-Hyperkalemia: it increases potassium release from intracellular stores.

3-Hyperthermia: with muscular rigidity and hyperpyrexia.


 Succinylcholine is considered a cholinergic antagonist (neuromuscular blocker).





 

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