Non selective Alfa and Beta receptors Fenoldopam and Amphetamine
Adrenergic agonist non selective Alfa and Beta Fenoldopam (Mechanism of action , pharmacological action , uses ,side effect , precaution )
Mechanism of action :
- as dopamine agonist drug As it stimulates the beta 1 receptors present in the heart, and in larger doses it affects the alpha receptors present in the blood vessels, causing constriction .
- calculating the dose is important, more or less, because the receptors on the heart will be affected by small doses, unlike those on the blood vessels.
Pharmacological action :
- This drug affects the D1 receptors on the coronary arteries that supply vasodilation to the heart muscle.
- Increases blood perfusion to the digestive system and kidneys due to D1 receptors.
Uses :
It is mostly used only in hospitals due to the large number
of side effects. Fast acting as a
vasodilation and pressure reliever .
Side effect :
- Arrhythmia .
- Headache due to vasodilation.
- Vomiting and nausea due to crossing the CNS.
- tachycardia.
- flushing due to the expansion of blood vessels in the face .
What is the mechanism of giving it and is it permissible to
take it orally ??
It is taken intravenously only to give a quick effect and is
not taken orally due to first pass metabolism .
Adrenergic agonist non selective Amphetamine ( Mechanism of action , pharmacological action , uses , side effect , precaution )
Mechanism of action :
It is considered indirectly effective on alpha and beta receptors because it increased the synthesis of dopamine and norepinephrine. By raising the pressure and by the action of tacicardia by its effect on beta1.
Pharmacological action :
Increases attention,
focus and activity .
Uses :
- It is used for children who have lethargy, sleep a lot, or deficit syndrome .
- It is used to control weight to reduce appetite.
- People who have distracted focus and can't focus.
- It is a strong stimulant on CNS system .
Side effect :
It is used in certain doses because it increases blood
pressure and heart rate .
Contraindication :
- Caution must be taken when taking it, especially for people with a bad chronic history.
- It should not be given without a doctor’s prescription and consultation with a doctor.
- Frequent reviews must be made to ensure safety on the heart and blood vessels.
- It is not given to people who have hypersensitivity .