Pathological of arithmetic:
- part of the heart muscle dies, and an ischemic heart occurs, and a defect occurs in the heartbeat (a weak beat and a very strong beat, or an extra beat that is not at the right time, or even a beat that is less than the time, the arrhythmia occurs).
- The signal is transmitted in the opposite direction, for example sodium or potassium does not enter the heart Imprisoned inside it or blocked the potassium channel and so on...
quinidine, procainamide, disopyramide pharmacological action :
All of them reduce the contractility and strength of the heartbeat, as they prevent sodium by inhibiting the channel from entering the heart muscle by a small percentage, of course, so as not to cause heart failure, in addition to closing the calcium channel.
uses:
used in the treatment of purkinje fibers, irregularities in both ventricles and atria from and to .
side effects:
- quinidine:
since it works by blocking the alpha receptor, it will cause the same side effects that it used to cause, see the Doxazosin , Prazosin , Terazosin, were causing vasodilation .
- procainamide :
causes vasoconstriction, as it stimulates but does not block alpha receptors, and we conclude that it leads to a decrease in blood pressure, especially if it is taken by IV .
- disopyramide:
the same symptoms as the muscarinic antagonist, where constipation and dryness of the price ...
Of course, care must be taken with patients with kidney failure, because it may accumulate in the blood and lead to toxicity