Anti-hyperlipidemia ( Bile acid sequestrants )
Drugs:
1- Colesevelam
2- Colestlpol
3- Colestyramine
Mechanism of action:
We all know that the process of converting cholesterol into bile salt takes place in the liver. The drug's action is that it works to prevent the reabsorption of bile acids from the intestine.
Pharmacological action:
Colestipol reduces low density lipoprotein-C (LDL-C) and increases the level of triglycerides (which is unique to this drug because it works to reduce the level of glucose in the blood).
Colestipol has many uses, including:
1- It is used to treat both TypeIIA and TypeIIB hyperlipidemia.
2- It is used in the treatment of type 2 diabetes.
3- It is used to relieve due to the accumulation of bile acids in patients suffering from biliary stasis.
Side effect:
It causes digestive disorders, including: constipation, nausea and flatulence.
Drug interactions:
Bile acids sequestrants interfere with the absorption of: Vitamins (D, A, E, K), digoxin, warfarin, and thyroid hormone, so all of these vitamins are taken 4-6 hours before taking the bile acids sequestrants.