Non selective Alfa and beta Agonist > ephedrine and pseudoephedrine ( pharmacological action , uses , side effect , contraindication )

 


Non selective Alfa and beta Agonist > ephedrine and pseudoephedrine ( pharmacological action , uses , side effect , contraindication )


Ph. Action :

  • ·         On CVS  : we give a certain dose , so that it dose not go on Alfa 2 receptor , mostly work on Alfa 1 and Beta 1 receptor . the pseudoephedrine has low affinity on beta 2 receptor . this is  leading to stimulate of cardiac muscle causing vasoconstriction and increase in blood pressure by raise both heart movement systolic and diastolic .
  • ·         On lung :  just affected by ephedrine by working on beta 2 receptor which found in bronchial and bronchiolar tub , the ephedrine has bronchodilator effect  less than epinephrine .
  • ·         On CNS : ephedrine make as stimulation for central nervous system and it can cross it , pseudoephedrine has low stimulation effect so it can not cross central nervous , the Alfa 1 receptors  are responsible for giving a result .

 

Uses of ephedrine :

  •  it is a hypophilic agent  .
  • in cases low blood pressure .
  • to expand the airways .

  • to increase attention .
  •  decrease sleeping and disturbance .
  • it strengthens the performance of sports players .
  •   decrease lethargy  .

 

Uses of pseudoephedrine :

  •         mostly in cases of cold  .
  •          used orally .
  •         not used as bronchodilator .
  •         prevent the formation of mucus coming from the nose .
  •         nasal congestion  .

 

side effect :

such as  dopamine  and other drug non selective Alfa and Beta .

 

contraindication :

  •          both of these drugs feature ephedrine and pseudoephedrine characteristic as long duration action  because it is not affected by inhibitor agent , so no breaking will not happen ( they are not from the same dopamine , epinephrine and norepinephrine .
  •          cold medicines are often taken every 12 hours , like pseudoephedrine .
  • ·         ephedrine was discovered from plants by chance , the food and drug administration pulled it from the market , because if affected the heart due secretion and they also used as cannabis .

  •          pseudoephedrine is now illegal because it increases feeling of happiness due ( methamphetamine )  and abnormal activity .

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