Adrenergic agonist part 3 (Drug-Drug inter action , contraindication )
Drug-Drug inter action
Digioxin : drug used in control heart beats , arrhythmia , heart failure and most symptom on heart . The mechanism gives disturbance in heart beat and blood pressure this is leading to additive effects of epinephrine so management should be
avoided .
Anesthesia : especially if the drug is inhaled ( nitrous oxide , halothane … ) the mechanism gives sensitizing on heart muscle for patient , if response at high doses he might die resulting disturbance tachycardia so the management should be reduce doses at inhalation administration .
Non selective beta blockers : drugs used to reduce blood pressure by block beta 2 receptor so prevent agonist which makes as vasodilator effect of epinephrine and norepinephrine , but the alfa receptor not response for opposite effect . resulting increase blood pressure , the percentage of the drug in the blood increased , so the number of receptor decreased . the management should be avoid with epinephrine .
Contraindication :
Hyperthyroidism : the epinephrine my cause hypersensitive response in thyrotoxic patient by increased of production of adrenergic beta receptor . it cause heart disease , as for recommendations it must be given by small doses and it consists partial agonist .
Diabetes mellitus : epinephrine is help to regulate glucose in blood circulation resulting hyperglycemia . for this we will increase the dose of insulin .
The epinephrine used in emergency situation ,, gives ( intravenous ) rapid onset and duration by liver .
When gives ( intramuscular ) and may be gives subcutaneously to gives long t.5 .